Spoiler: Have a master Japanese chef prepare it for you.
It's not often that you sit down to eat a poisonous creature. The pufferfish—a.k.a. fugu or 河豚 in Japanese—is one of the deadliest fish out there, thanks to a naturally occurring neurotoxin called tetrodotoxin that it carries. With its toxic bits removed, however, fugu is a delicacy in Japan. Rumors abound that some aficionados keep a little poison intact because it makes the eater's lips tingle when they consume it.